Cannabidiol (CBD) is one of at least 85 cannabinoids found in the cannabis plant. Although THC is more often associated with cannabis plants, CBD is the most abundant, and has none of the psychoactive properties of the THC molecule. All cannabinoids act on cannabinoid receptors that are found in our body’s endocannabinoid system.
Recent research shows a number of potential benefits for our mental and physical health associated with CBD use. Some of the common effects include but are not limited to: increased levels of relaxation, heightened alertness, improved mental clarity, reduction in physical pain and inflammation, enhanced sleep, reduced anxiety and stress, and suppressed nausea.
No, research has shown the hemp-derived CBD that contains less than 0.3% THC does not produce psychoactive effects.
Whole Hemp Plant (known for producing the “entourage effect”) is a term used to describe when all the natural compound are kept in the cannabis plant, such as the cannabinoids, terpenes, and flavonoids. These compounds have been shown to work better when they are taken together. Products that are full spectrum contain CBD as well as other cannabinoids, while CBD isolate is nearly pure CBD without other cannabinoids and cannabis compounds.
Endocannabinoids (cannabinoids produced naturally in the body of mammals) are not neurotransmitters. Endocannabinoids are neuromodulators – they are released on demand to alter the activity of neurotransmitters. A good example is glutamate. Glutamate is a primary, stimulatory neurotransmitter. When glutamate is present in excessive amounts, pain and cell death can occur. The release of endocannabinoids functions as a stopping mechanism for the release of glutamate. CBD can act in the same way as our own endocannabinoids.
The endocannabinoid system is the collection of cannabinoid receptors, endocannabinoids (cannabinoids produced naturally in our bodies) and enzymes involved in producing and breaking down endocannabinoids. It is an integral part of our neuro-immuno-endocrine network. This system affects many aspects of human health including mood, pain, inflammation, stress responses and immune functionality.
The two most studied endocannabinoids are anandamide and 2-AG. The two most studied cannabinoid receptors are CB1 and CB2. CB1 receptors are located mostly in the brain and CB2 receptors are located mostly throughout the immune system. A “phytocannabinoid” or plant-derived cannabinoid like CBD can activate the same receptors in the body and may have similar or stronger effects than the endocannabinoids that our bodies produce naturally.
CBD bioavailability generally refers to how quickly the CBD enters your bloodstream and is made available to your body’s circulation system. The higher the bioavailability, the faster the CBD will take effect in your body and, likely, the stronger effect on your body.