Dr. Chris Meletis discusses how CBD works with your body’s CB2 receptors to act like a 9-Volt battery for your joints by recharging overused and tired joints. CBD works to block inflammation and prevents the release of immune factors that can negatively impact joint health. The end result is increased comfort and decreased stiffness — in other words: wellbeing.

If you’re suffering from pain, cannabidiol (CBD) oil can be one of your best friends. I often use it in my clinical practice to support the health of patients with hip and knee joint pain, neck pain, back pain, and nerve pain. If you’re having any of these problems, you’re not alone. Pain is one of the most common reasons patients visit my office. 

You can tell that sore joints and other similar problems are really common just by looking at opioid drug sales. They quadrupled from the years 1999 to 2014. Opioids are a class of drugs used to treat common pain. However, opioids are addictive and can lead to overdose. 


What Do Pain Relief and a 9-Volt Battery Have in Common?

CBD has experienced extreme popularity as a natural alternative for controlling bodily discomfort. CBD comes from the hemp plant. It’s also a component of marijuana but it doesn’t get you high. CBD acts on the CB2 receptor. Think of a receptor like the sockets you plug a 9-volt battery into on your smoke detectors, sprinkler system, or other devices. Once that battery connects with those receptors it powers whatever device it’s plugged into. 

It works the same with CB2 receptors. When CBD is plugged into those receptors it can boost your health in many ways. CB2 receptors—and CBD acting on those receptors—indirectly activate the same receptors as opioid drugs. CBD also acts on other receptors in the body. The end result? Improved comfort in joints that have experienced overuse. Or less stiffness in your back or neck. 


Natural Pain Relief Courtesy of CBD

Human studies, animal studies, and experience from clinical practice show CBD may lead to less discomfort. In a study of seven kidney transplant patients experiencing pain, the pain disappeared completely in two patients. Four patients had a partial improvement. In another study, CBD oil reduced body pain and improved other symptoms in girls who had a bad reaction to the human papillomavirus (HPV) vaccine. 

In rodents, topical, oral, and injected CBD oil reduced pain and improved joint health. CBD even worked in advance. That means when it was given to the rodents before they developed the joint problems, it stopped those problems from occurring in the first place. 

In supporting joint health, CBD works in two ways. First, it blocks inflammation.8 Second, it stops the release of immune factors that can wreak havoc on joint health.


Choosing the Best CBD Oil for Pain

For the best results, it’s important to start slowly. CBD impacts what’s known as the endocannabinoid system. If you start with too high a dose you could throw this system out of whack. Finally, it’s really important to use the highest quality CBD oil. This means one that’s non-GMO and organic, and one you can trust to be THC-free or that has no more than the legal limit of 0.3% THC. You can find that type of CBD oil here



  1. Centers for Disease Control and Prevention. https://www.cdc.gov/drugoverdose/data/prescribing.html Accessed June 7, 2019.
  2. Ibrahim MM, et al. CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3093-8.
  3. Cuñetti L, Manzo L, Peyraube R, et al. Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay. Transplant Proc. 2018 Mar;50(2):461-4. 
  4. Palmieri B, Laurino C, Vadalà M. Short-Term Efficacy of CBD-Enriched Hemp Oil in Girls with Dysautonomic Syndrome after Human Papillomavirus Vaccination. Isr Med Assoc J. 2017 Feb;19(2):79-84.
  5. Philpott HT, O’Brien M, McDougall JJ. Attenuation of early phase inflammation cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017 Dec;158(12):2442-51.
  6. Hammell DC, Zhang LP, Ma F, et al. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Eur J Pain. 2016 Jul;20(6):936-48.
  7. Costa B, Colleoni M, Conti S, et al. Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar;369(3):294-9. 
  8. Malfait AM, Gallily R, Sumariwalla PF, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9561-6.


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